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The story follows Peter Bretter (Jason Segal), a guy who's doing well for himself. He writes and performs the musical score for a successful TV show and dates the hot TV Star Sarah Marshall. Peter is left heart broken when he is dumped and decides to go to Hawaii to try and get over his pain and change his life for the better. Little does he know that Sarah has also travelled to Hawaii with her new boyfriend. With the help of his new friends and a possible new love interest Peter tries to forget about Sarah Marshall.